Diagnose von Weichteiltumoren in der Zytologie

Zusammenfassung: Weichteilschwellungen sind das Symptom einer Vielzahl von neoplastischen und nichtneoplastischen Veränderungen. Sarkome gehören zu den selteneren Ursachen. Die Feinnadelpunktion hat sich in der Abklärung von Tumorrezidiven und Karzinommetastasen als minimal-invasive, kostengünstige und zuverlässige Methode bewährt. Auch in der Abklärung von Weichteiltumoren kann sie zu einer präzisen Diagnose führen. Voraussetzung ist eine enge multidisziplinäre Zusammenarbeit unter Einbeziehung klinischer, radiologischer und morphologischer Befunde. Für die zytologische Befundung sind Alter und Geschlecht sowie Topographie, Größe und Wachstumsgeschwindigkeit des Tumors wichtige Parameter. Reifungsgrad und Form der Zellen sowie Vorhandensein und Ausdifferenzierung der bindegewebigen Matrix bieten erste differenzialdiagnostische Hinweise und sind der Ausgangspunkt für immunzytochemische und molekularbiologische (FISH, RT-PCR) Zusatzuntersuchen. Diese Untersuchungen werden an Direktausstrichen, an mittels Zellblockmethode eingebettetem und an tiefgefrorenem Punktionsmaterial ausgeführ

Zytologische Sarkomdiagnostik

Zusammenfassung: Weichteilschwellungen sind das Symptom einer Vielzahl neoplastischer und nichtneoplastischer Veränderungen. Sarkome gehören zu den selteneren Ursachen. Die Feinnadelpunktion (FNP) hat sich in der Abgrenzung zu entzündlichen Prozessen sowie in der Abklärung von Tumorrezidiven und Karzinommetastasen als minimal-invasive, kostengünstige und zuverlässige Methode bewährt. Auch in der Abklärung von Weichteiltumoren kann sie zu einer präzisen Diagnose führen. Voraussetzung ist eine enge multidisziplinäre Zusammenarbeit unter Einbeziehung klinischer, radiologischer und morphologischer Befunde. Für die zytologische Befundung sind Alter und Geschlecht sowie Topographie, Größe und Wachstumsgeschwindigkeit des Tumors wichtige Parameter. Reifungsgrad und Form der Zellen sowie Vorhandensein und Ausdifferenzierung der bindegewebigen Matrix bieten erste differenzialdiagnostische Hinweise und sind der Ausgangspunkt für immunzytochemische und molekularbiologische (FISH, RT-PCR) Zusatzuntersuchungen. Diese Untersuchungen werden an Direktausstrichen, an mittels Zellblockmethode eingebettetem und an tiefgefrorenem Punktionsmaterial ausgeführ

Rolle der Zytologie in der hämatopathologischen Diagnostik

Zusammenfassung: Die Zytologie stellt ein wichtiges diagnostisches Instrument in der täglichen Praxis der Hämatopathologie dar. Durch den zytologisch erfolgten Nachweis nichthämatologischer Ursachen einer Knotenbildung (z.B. Speicheldrüsenneoplasien, Tuberkulose, Melanom- oder Karzinommetastasen) besteht seltener die Notwendigkeit einer chirurgischen Exzision. Die kombinierte Anwendung morphologischer, immunphänotypischer sowie molekularer Analysen und der fachliche Austausch machen diese Untersuchungstechnik sicher. Somit stellt die zytologische Untersuchung in verschiedensten Situationen eine Alternative zur Exzisionsbiopsie dar - auch bei primären hämatologischen Erkrankungen und insbesondere bei Rezidive

Spin-polarized surface states close to adatoms on Cu(111)

We present a theoretical study of surface states close to 3d transition metal adatoms (Cr, Mn, Fe, Co, Ni and Cu) on a Cu(111) surface in terms of an embedding technique using the fully relativistic Korringa-Kohn-Rostoker method. For each of the adatoms we found resonances in the s-like states to be attributed to a localization of the surface states in the presence of an impurity. We studied the change of the s-like densities of states in the vicinity of the surface state band-edge due to scattering effects mediated via the adatom's d-orbitals. The obtained results show that a magnetic impurity causes spin-polarization of the surface states. In particular, the long-range oscillations of the spin-polarized s-like density of states around an Fe adatom are demonstrated.Comment: 5 pages, 5 figures, submitted to PR

Determination of the Her-2/neu gene amplification status in cytologic breast cancer specimens using automated silver-enhanced in-situ hybridization (SISH)

Silver-enhanced in-situ hybridization (SISH) is an emerging tool for the determination of the Her-2/neu amplification status in breast cancer. SISH is technically comparable to fluorescence in-situ hybridization (FISH) but does not require a fluorescence microscope for its interpretation. Although recent studies on histologic evaluations of SISH are promising, we aimed to evaluate its performance on 71 cytologic breast cancer specimens with the new combined Her-2/Chr17 probe. Her-2/neu status as routinely determined by FISH was available for all patients. We found SISH signals in cytologic cell blocks and smear specimens easy to evaluate in most cases. Small numbers of tumor cells and difficulties in identifying tumor cells in lymphocyte-rich backgrounds were limiting factors. Her-2/neu status, as determined by Her-2/Chr17 SISH, was basically identical to the results of the corresponding FISH. The discrepancies were mainly owing to the heterogeneity of Her-2/neu amplification in the tumor tissue. Interobserver agreement for the SISH evaluation was high (kappa value: 0.972). We conclude that Her-2/Chr17 SISH is a useful and accurate method for the evaluation of the Her-2/neu gene amplification status in cytologic breast cancer specimens, particularly in metastatic breast cancer lesions. The advantages of signal permanency and bright-field microscopic result interpretation make this technique an attractive alternative to the current FISH-based gold standard

Improving Performance of Iterative Methods by Lossy Checkponting

Iterative methods are commonly used approaches to solve large, sparse linear systems, which are fundamental operations for many modern scientific simulations. When the large-scale iterative methods are running with a large number of ranks in parallel, they have to checkpoint the dynamic variables periodically in case of unavoidable fail-stop errors, requiring fast I/O systems and large storage space. To this end, significantly reducing the checkpointing overhead is critical to improving the overall performance of iterative methods. Our contribution is fourfold. (1) We propose a novel lossy checkpointing scheme that can significantly improve the checkpointing performance of iterative methods by leveraging lossy compressors. (2) We formulate a lossy checkpointing performance model and derive theoretically an upper bound for the extra number of iterations caused by the distortion of data in lossy checkpoints, in order to guarantee the performance improvement under the lossy checkpointing scheme. (3) We analyze the impact of lossy checkpointing (i.e., extra number of iterations caused by lossy checkpointing files) for multiple types of iterative methods. (4)We evaluate the lossy checkpointing scheme with optimal checkpointing intervals on a high-performance computing environment with 2,048 cores, using a well-known scientific computation package PETSc and a state-of-the-art checkpoint/restart toolkit. Experiments show that our optimized lossy checkpointing scheme can significantly reduce the fault tolerance overhead for iterative methods by 23%~70% compared with traditional checkpointing and 20%~58% compared with lossless-compressed checkpointing, in the presence of system failures.Comment: 14 pages, 10 figures, HPDC'1

Solitary fibrous tumor of the orbit—two cases and a review of the literature

Solitary fibrous tumors of the orbit (SFT) are mesenchymal lesions that can develop either as malignant or benign neoplasias. We describe the histological features leading to the diagnosis in two females and review the current literature. Diagnosis of SFT only can be performed by histological examination, since clinical signs and radiological features are not specific enough. Even a malignant or benign course cannot be predicted, since clinical and radiological features do not correlate with histological signs of malignancy and vice versa. Radical resection is the treatment of choice, since no other treatment option has been proven to be efficien

Bauran Pemasaran Pengaruhnya terhadap Minat Membeli Kembali Voucher Isi Ulang Telkomsel

Perusahaan operator telepon seluler memerlukan cara yang kreatif untuk mempengaruhi keputusan pembelian konsumen. Salah satu strategi dalam memenangkan pasar, yaitu strategi bauran pemasaran atau marketing mix. Penelitian ini bertujuan untuk mengetahui pengaruh produk, promosi, harga dan tempat terhadap Minat Beli ulang Voucher Telkomsel pada Mahasiswa Fakultas Ekonomi dan Bisnis (FEB) Universitas Sam Ratulangi di kota Manado, penelitian ini menggunakan Metode asosiatif dengan teknik Analisis Regresi Linear Berganda dan sampel berjumlah 100 orang menggunakan teknik pengambilan sampel Slovin. Hasil analisis diperoleh bahwa produk, promosi, harga dan tempat berpengaruh positif baik secara simultan maupun parsial terhadap keputusan pembelian ulang vouher isi ulang Telkomsel. Untuk meningkatkan kepuasan konsumen hendaknya pihak manajemen memberikan perhatian pada promosi dan harga sehingga dapat meningkatkan minat membeli ulang dari konsumen Kata kunci: produk, promosi, harga, tempat, keputusan pembelian ulan

Evolution of the Cluster Correlation Function

We study the evolution of the cluster correlation function and its richness-dependence from z = 0 to z = 3 using large-scale cosmological simulations. A standard flat LCDM model with \Omega_m = 0.3 and, for comparison, a tilted \Omega_m = 1 model, TSCDM, are used. The evolutionary predictions are presented in a format suitable for direct comparisons with observations. We find that the cluster correlation strength increases with redshift: high redshift clusters are clustered more strongly (in comoving scale) than low redshift clusters of the same mass. The increased correlations with redshift, in spite of the decreasing mass correlation strength, is caused by the strong increase in cluster bias with redshift: clusters represent higher density peaks of the mass distribution as the redshift increases. The richness-dependent cluster correlation function, presented as the correlation-scale versus cluster mean separation relation, R_0 - d, is found to be, remarkably, independent of redshift to z <~ 2 for LCDM and z <~ 1 for TCDM (for a fixed correlation function slope and cluster mass within a fixed comoving radius). The non-evolving R_0 - d relation implies that both the comoving clustering scale and the cluster mean separation increase with redshift for the same mass clusters so that the R_0 - d relation remains essentially unchanged. The evolution of the R_0 - d relation from z ~ 0 to z ~ 3 provides an important new tool in cosmology; it can be used to break degeneracies that exist at z ~ 0 and provide precise determination of cosmological parameters.Comment: AASTeX, 15 pages, including 5 figures, accepted version for publication in ApJ, vol.603, March 200